Institute of Chemical Physics

Development of techniques which can intensify regenerative processes

in the body is one of important approaches of the contemporary

personalized medicine aimed at the repair of the lost tissues’ structure

and functionality. To successfully achieve that goal, synthetic

biocompatible materials may be used which make a basis for carrier

matrices (scaffolds) with several functions in the tissue regeneration.

First of all, such scaffolds create a supporting frame, at the same time

being a carrier of autologous cells and substances which intensify cell

proliferation and differentiation. The modern biomedical materials

science is an interdisciplinary field of research, including a chemical

(synthesis of new substances, functionalization of new materials’

surface), physical (materials structuring, their characterization and

visualization) and a biological (evaluation of biocompatibility)

directions of studies. The main mission of the Department of Modern

Biomaterials is the development of approaches to creation of

biocompatible carrier matrices based on modern chemical technology

and 3D printing, as well as the development of the ways to improve the

artificial materials’ compatibility with living systems and the ways of

intensification of regenerative processes. A crucial requirement to the

cell carrier matrix is a possibility of its destruction in vivo, which should

lead to the total desorption of the artificial material when the

regeneration is completed. At the same time, the rate of the matrix

degradation should correspond to the rate of a new tissue growth, to

provide the highest efficiency of the regenerative process. Degradation

of a cell carrier matrix in vivo is a complex multifactorial process, the

rate of which is determined both by the surrounding tissue and by the

properties of the matrix itself: its chemical composition, molecular

weight and polydispersity; presence of low-molecular components and

ionic groups; morphology (crystallinity); techniques and parameters of

its structuring; sterilization technique; physico-chemical factors (size,

shape) and a number of others. The studies within the Department are

directed towards the solution of fundamental problems of the modern

biomedical materials science and include applied research in the field of

creation and functionalization of materials for regenerative medicine.

For the successful realization of the set goals, the Department of Modern

Biomaterials performs collaborated studies with leading Russian and

foreign research institutes:

Institute of photonic technologies, Federal Scientific Research Center

“Crystallography and Photonics” of RAS (Troitsk, Moscow)

Institute of Chemical Physics (Moscow)

Baikal Institute of Nature Management, Siberian Branch of RAS (Ulan-

Ude)

Hannover Lazer Zentrum (Hannover, Germany)

National University of Ireland (Galway, Ireland)