Репозиторий Университета

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. The physicochemical and technological properties of an interpolymer complex of polymethyacrylic acid and polyethylene glycol, known under its commercial name “Polymer Carrier Composition” (FGUP Science Research Institute of Polymers, Russia), were studied. This polymer is an excipient substance used in the technology of solid dosage forms as a matrix former and as a film-forming agent for making long-acting and slow-release formulations. With the aim of widening the potential uses of the polymer carrier composition, the solubility of the polymer in aqueous solutions and organic solvents was studied, along with the technological and surfactant properties of the polymer; the critical gel-forming concentration was also determined. Experimental samples of tablets and oral gels of model substances with similar physicochemical properties were prepared, based on different concentrations of the Polymer Carrier Composition, and the technological, rheological, and biopharmaceutical properties of these were studied. The potential for using the polymer in both hard and soft dosage forms to obtain prolonged-release medicinal formulations is demonstrated.

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Technology development for solid dosage forms with a solid dispersion of diclofenac is a crucial problem in pharmaceutical science and practice. The goal of the work was science-based and experimental technology development for tablets containing a solid dispersion of diclofenac with improved biopharmaceutical indicators as an equivalent to the substance. The obtained granulates and tablets had indicators that met the corresponding standards of the Russian SP XIIIth Ed. Almost 100% of the diclofenac was released from the developed tablets. This was 1.3 times greater than from commercial tablets. The recommended shelf life under these conditions is two years. The proposed technology could not only increase the bioavailability of the slightly soluble non-salt form of diclofenac but also facilitate further development of new medicinal preparations with improved bioavailability.

© 2018, Pleiades Publishing, Ltd. A rapid method is developed for the quantitative determination of 5–35 g/L of isonicotinic hydrazide (INH, isoniazide) in aqueous media. The method is based on the formation of copper(I) oxide in the reaction of isonicotinic hydrazide with copper ions on the surface of indicator tablets and the subsequent recording of the analytical signal by reflectance spectrophotometry and colorimetry. Aluminum oxide is proposed as a solid-phase substrate for the production of indicator tablets. Isonicotinic hydrazide can be determined in the tablet form of the Isoniazid preparation.