Репозиторий Университета

© 2021 Elsevier B.V. Innovative Mn-containing glass ceramic (Na2O[2.00]-K2O[0.09]-MgO[3.10]-MnO[2.07]-CaO[38.78]-CaF2[2.25]-P2O5[9.66]-SiO2[41.71] [wt%]) was obtained by sol-gel. It was investigated by High Resolution Field Emission Scanning Electron Microscopy, Energy Dispersive X-Ray Spectroscopy, X-Ray fluorescence, X-Ray Diffraction, and Fourier Transform Infrared Spectroscopy. Ion release characteristics of the glass ceramic powder were quantified via Inductively Coupled Plasma Optical Emission Spectroscopy. Biological tests were performed using equine adipose tissue mesenchymal stem cells (AMSCs). MTT assay demonstrated the cytocompatibility of the prepared material. AMSCs differentiation test showed that the glass ceramic favored the stem cell differentiation in adipogenic, chondrogenic, and osteogenic lineages, the last one being qualitatively more pronounced. The antimicrobial properties were evaluated against Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Salmonella typhi, and Staphylococcus aureus bacteria strains and Candida albicans fungus. The inhibition of Gram-negative bacteria (S. tiphy, E. coli), Gram-positive (E. faecalis) and fungus (C. albicans) was detected, while the inhibition of P. aeruginosa and S. aureus was not significant.

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. We carried out a comparative study of the features of osteogenesis from the progenitor osteogenic periosteal cells in rabbit and human. At the initial stages, high osteogenic potential of both human and rabbit periosteal cells was observed. However, at the later stages, the cell response favors resorption of the new bone tissue formed from periosteal cells in rabbits, but does not affect the bone tissue formed from human progenitor osteogenic periosteal cells. These functional characteristics of rabbit periosteal cells should be considered when planning the experiment.