Год публикации:
Все года
2018
2019
2020
| Название |
Дата публикации |
Коллектив авторов |
Журнал |
DOI |
Индекс цитирования |
Ссылка на источник |
|
Dinitrosyl Iron Complexes in the Sensitized Oxidation of Organic Substrates
|
01.09.2019 |
Solov’eva A.
Glagolev N.
Aksenova N.
Kur’yanova A.
Vanin A.
Timofeeva V.
Timashev P.
|
Russian Journal of Physical Chemistry A |
10.1134/S0036024419090267 |
0 |
Ссылка
© 2019, Pleiades Publishing, Ltd. Abstract: It is shown that the efficacy of the photosensitized oxidation of organic substrates in aqueous media (with the oxidation of tryptophan being used as an example) does not depend on adding biologically active dinitrosyl iron complexes (DNICs) with thiol-containing ligands to the reaction medium if it contains Pluronic F127, a poly(ethylene oxide)–poly(propylene oxide)– poly(ethylene oxide) triblock copolymer, at concentrations higher than the critical micelle concentration. Photosensitizer molecules are localized in Pluronic micelles and are shielded from the damaging impact of NO• radicals that form upon the photodegradation of DNIC molecules. Photodynamic therapy (PDT) sessions (the photoinduced necrosis and apoptosis of cells in pathologically altered tissues and the simultaneous initiation of regeneration and repair of the treated tissues due to the photodecomposition of DNIC molecules) thus become fundamentally possible.
Читать
тезис
|
|
Photosensitizing Activity of Steroid Derivatives of Pyropheophorbide in the Oxidation of Tryptophan in the Aqueous Phase
|
01.09.2018 |
Solov’eva A.
Kur’yanova A.
Savko M.
Aksenova N.
Afanas’evskaya E.
Zolottsev V.
Taratynova M.
Ponomarev G.
Timashev P.
|
Russian Journal of Physical Chemistry A |
|
0 |
Ссылка
© 2018, Pleiades Publishing, Ltd. Solubilization with pluronic F-127 gave water-soluble forms of hydrophobic photosensitizers—steroid derivatives of pyropheophorbide a. Solubilization was performed by evaporating the chloroform co-solutions of photosensitizer and pluronic (triple block copolymer of ethylene and propylene oxide) and subsequently dissolving the resulting dry residue in water. The concentration ratios of modified pyropheophorbide–pluronic at which the photosensitizer completely passed into the aqueous phase were determined. Among the starting hydrophobic photosensitizers, pyropheophorbide–dihydrotestosterone possessed the highest activity in photosensitized oxidation of anthracene with singlet oxygen in chloroform, while after solubilization, pyropheophorbide–testosterone was most active in the test (for photodynamic therapy) oxidation of tryptophan in aqueous solutions.
Читать
тезис
|
|
Studies of the Association between the Kynurenine-3-Monooxygenase Gene and Depression
|
01.05.2018 |
Lezheiko T.
Golimbet V.
Andryushchenko A.
Melik-Pashayan A.
Mironova E.
|
Neuroscience and Behavioral Physiology |
|
0 |
Ссылка
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Objective. To study the association between the kynurenine-3-monooxygenase (KMO) gene and depression. Materials and methods. Polymorphic loci rs2275163 (C/T) and rs1053230 (A/G) of the KMO gene were studied in patients with depression (study group) and mentally healthy subjects of comparable gender and age (control group). Results and conclusions. The rs2275163 polymorphism was not associated with depression. An association between the rs1053230 polymorphism and depression was found. The frequency of the GG genotype, linked with lower KMO activity and increased kynurenic acid levels in patients with endogenous psychoses, was greater in the study group than the control group (p = 0.001, OR 2.8 (95% CI 1.73–4.24). thus, the GG genotype can be regarded as a risk allele for developing depression.
Читать
тезис
|
