Репозиторий Университета

Год публикации: Все года 2018 2019 2020

Название	Дата публикации	Коллектив авторов	Журнал	DOI	Индекс цитирования	Ссылка на источник
HPLC-MS/MS Method for Determining Dabigatran in Human Blood Serum dabigatran dabigatranetexilate HPLC-MS/MS noveloralanticoagulants(NOACs) therapeuticdrugmonitoring	01.03.2018	Rodina T. Mel’nikov E. Aksenov A. Belkov S. Sokolov A. Prokof’ev A. Ramenskaya G.	Pharmaceutical Chemistry Journal		1	Ссылка © 2018, Springer Science+Business Media, LLC, part of Springer Nature. An HPLC-MS/MS method for determining dabigatran in human blood serum was developed. Samples were prepared by precipitation of proteins using MeOH followed by centrifugation and dilution with deionized H2O. The developed method had a simple sample-preparation procedure, short analysis time, and wide analytical range (from 1 to 1,000 ng/mL). This method was suitable for routine bioanalytical studies, in particular, therapeutic drug monitoring. Читать тезис
Simultaneous Determination of Metoprolol and Bisoprolol in Human Serum by HPLC-MS/MS for Clinical Drug Monitoring arterialhypertension bisoprolol HPLC-MS/MS metoprolol therapeuticdrugmonitoring	01.03.2018	Rodina T. Mel’nikov E. Dmitriev A. Belkov S. Sokolov A. Arkhipov V. Prokof’ev A.	Pharmaceutical Chemistry Journal		1	Ссылка © 2018, Springer Science+Business Media, LLC, part of Springer Nature. A method for simultaneous determination of metoprolol and bisoprolol in human blood serum by HPLC-MS/MS was developed and validated. The analytical ranges of the method were 5 – 250 ng/mL and 1 – 250 ng/mL for metoprolol and bisoprolol, respectively. The suitability of the developed for therapeutic drug monitoring during treatment for arterial hypertension and other cardiovascular diseases was demonstrated. In particular, the proposed method could identify patients at high risk for developing adverse effects and help to monitor a switch between metoprolol and bisoprolol while changing the pharmacotherapy regime. Читать тезис

Репозиторий Университета

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