Год публикации:
Все года
2018
2019
2020
Название |
Дата публикации |
Коллектив авторов |
Журнал |
DOI |
Индекс цитирования |
Ссылка на источник |
Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin
|
01.06.2018 |
Krasnyuk I.
Kosheleva T.
Belyatskaya A.
Stepanova O.
Skovpen Y.
Grikh V.
Ovsyannikova L.
|
Pharmaceutical Chemistry Journal |
|
0 |
Ссылка
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H2O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 – 2.2 and 3.1 – 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions.
Читать
тезис
|