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Doxylamine and melatonin in treatment of sleep disruption in gynecological practice
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01.01.2018 |
Burchakov D.
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Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova |
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Symptoms of sleep disruption are widely prevalent in general population, but they are not necessarily form the full clinical presentation of insomnia. Diagnostic process should consider somatic diseases usually accompanied by sleep disruption. This review presents the data on insomnia symptoms in gynecological diseases: menstrual cycle related disorders, endometriosis, peri- and postmenopausal symptoms.
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Hypnotics: Past, presence, future
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01.01.2018 |
Churyukanov V.
Lemina E.
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Eksperimental'naya i Klinicheskaya Farmakologiya |
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© 2018 Izdatel'stvo Meditsina. All rights reserved. This article provides a short history of the creation of hypnotics, examines their mechanisms of action, and conducts a comparative analysis of the main groups of hypnotics such as barbiturates, benzodiazepines, "nonbenzodiazepine" benzodiazepine receptor agonists, melatonin receptor agonists, orexin receptor antagonists, histamine H1-receptor antagonists.
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Sleep and wakefulness disorders in neurodegenerative diseases
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01.01.2018 |
Yakovleva O.
Poluektov M.
Levin O.
Lyashenko E.
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Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova |
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The article reviews the phenomenology of sleep and wakefulness disorders in Parkinson's disease and Alzheimer's disease. Degeneration of sleep and wakefulness centers, secondary effect of other symptoms of diseases and side-effects of drug therapy lead to a widespread prevalence of sleep and wakefulness disturbances in these patients. Along with the review of actual literature concerning mechanisms of development and clinical features of these disorders, the authors discuss principal methods for their treatment.
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Determination of the level of anti bodies to melatonin 1a receptor in children with diabetes mellitus in different stages of the disease
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01.01.2018 |
Baturin V.
Bykov Y.
Mamtseva G.
Uglova T.
Yagudina R.
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Medical News of North Caucasus |
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© 2018 Stavropol State Medical University. All Rights Reserved. Type I Diabetes mellitus (DM), or insulin-dependent diabetes, is the most common endocrine pathology among children and teenagers. The purpose of this study is to research the content of 1A melatonin receptor and antibodies to it in blood serum of children and teenagers. We examined 71 children and teenagers aged 1.9 to 17 years. We measured the content of 1A melatonin receptor and antibodies to it in hemolymph using an immunofluorescence assay test system (IFA). We found that the lowest levels of the 1A melatonin receptor were prevailing in children with a serious condition at the DM decompensation stage, median values were diagnosed in children in a state of moderate severity, and the maximum quantities are fixed in children against the background of the compensation of DM. The obtained data confirm the hypothesis about the possible involvement of the corpus pineale (epiphysis) in the pathogenesis of Type I Diabetes mellitus.
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