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Preparation of Low-Molecular-Weight Heparins by Radiation-Induced Destruction
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01.05.2018 |
Tuaeva N.
Trukhan V.
Kardonskii D.
Eganov A.
Grebenkina E.
Veselov V.
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Pharmaceutical Chemistry Journal |
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0 |
Ссылка
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Low-molecular-weight heparins (LMWHs) are widely used in medical practice. LMWHs are produced using various methods of controlled depolymerization of unfractionated heparin (UFH). Herein, a method for radiation-induced destruction of aqueous heparin solutions using a 60Co gamma-irradiation source is presented. The optimal conditions for depolymerization of starting heparin were found. The anticoagulant activity of LMWHs was studied as a function of irradiation dose. The results allowed this LMWH production method to be recommended for development of new anticoagulants.
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