Репозиторий Университета

Год публикации: Все года 2018 2019 2020

Название	Дата публикации	Коллектив авторов	Журнал	DOI	Индекс цитирования	Ссылка на источник
Role of mesenchymal multipotent stromal cells in remodeling of bone defects Bonebioimplants Immunomodulatingactivity Mesenchymalmultipotentstromalcells Osteoimmunology Tissueengineeringconstructions	01.01.2018	Kiselevsky M. Anisimova N. Dolzhikova Y. Vlasenko R. Senatov F. Karaulov A.	Medical Immunology (Russia)		0	Ссылка © 2018, SPb RAACI. Ability of mesenchymal multipotent stromal cells (MSCs) to differentiate into several types of mesenchymal tissues allows to consider these cells the main candidates for creating tissue engineering constructions for regenerative medicine. MSCs promote integration of bio-implants into the native bone and stimulate osteogenesis. MSCs are characterized by immunomodulatory properties, due to inflammation control and modification of immune cells. MSCs affect not only the in vivo immune response by preventing immunological rejection of implanted tissue engineering designs, but it can also influence the bone tissue immunity. MSCs play an important role in bone regeneration, by regulating the osteoblastic generation, and suppressing activity of inflammation effectors and osteoclastogenesis. Some pre-clinical and first clinical trials of bone bio-implants colonized with MSC, demonstrate promising outlooks for this strategy in order to obtain tissue engineering constructions for bone regeneration. Читать тезис

Репозиторий Университета

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