Репозиторий Университета

Год публикации: Все года 2018 2019 2020

Название	Дата публикации	Коллектив авторов	Журнал	DOI	Индекс цитирования	Ссылка на источник
Mitochondrial calcium uniporter structure and function in different types of muscle tissues in health and disease Calcium Calciumhomeostasis Calciumsignaling Mitochondrialcalciumuniporter Myocardium Regulatorypathways Skeletalmuscle Smoothmuscle	01.10.2019	Tarasova N. Vishnyakova P. Logashina Y. Elchaninov A.	International Journal of Molecular Sciences	10.3390/ijms20194823	1	Ссылка © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Calcium ions (Ca2+) influx to mitochondrial matrix is crucial for the life of a cell. Mitochondrial calcium uniporter (mtCU) is a protein complex which consists of the pore-forming subunit (MCU) and several regulatory subunits. MtCU is the main contributor to inward Ca2+ currents through the inner mitochondrial membrane. Extensive investigations of mtCU involvement into normal and pathological molecular pathways started from the moment of discovery of its molecular components. A crucial role of mtCU in the control of these pathways is now recognized in both health and disease. In particular, impairments of mtCU function have been demonstrated for cardiovascular and skeletal muscle-associated pathologies. This review summarizes the current state of knowledge on mtCU structure, regulation, and function in different types of muscle tissues in health and disease. Читать тезис

Репозиторий Университета

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