Репозиторий Университета

Год публикации: Все года 2018 2019 2020

Название	Дата публикации	Коллектив авторов	Журнал	DOI	Индекс цитирования	Ссылка на источник
The dopaminergic dysfunction and altered working memory performance of aging mice lacking gamma-synuclein gene Andamphetamineinducedlocomotion Gamma-synuclein Neuraltissue Passive-avoidancetest Solubleproteins Workingmemory	01.01.2018	Kokhan V. Kokhan T. Samsonova A. Fisenko V. Ustyugov A. Aliev G.	CNS and Neurological Disorders - Drug Targets		0	Ссылка © 2018 Bentham Science Publishers. Background: It was previously shown that inactivation of gamma-synuclein which is a small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out mice. Objective: Determine the role of gamma-synuclein inactivation on memory performance in aging animals. Method: We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice. Results: As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle trafficking machinery impairment was obtained. Conclusion: Therefore most likely these dysfunctions are associated with a reduction in the highefficient learning performance in tests that require intact working memory. Читать тезис