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Isolation and characterization of Wad Medani virus obtained in the tuva Republic of Russia
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01.03.2021 |
Dedkov V.G.
Dolgova A.S.
Safonova M.V.
Samoilov A.E.
Belova O.A.
Kholodilov I.S.
Matsvay A.D.
Speranskaya A.S.
Khafizov K.
Karganova G.G.
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Ticks and Tick-borne Diseases |
10.1016/j.ttbdis.2020.101612 |
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Ссылка
© 2020 Elsevier GmbH Wad Medani virus (WMV) belongs to the genus Orbivirus and is a poorly studied arbovirus with unclear medical significance. Presently, a limited number of WMV strains are characterized and available in NCBI GenBank, some isolated many years ago. A new WMV strain was isolated in 2012 from Dermacentor nuttalli ticks collected from sheep in the Tuva Republic, Russia, and sequenced using high-throughput methods. Complete coding sequences were obtained revealing signs of multiple intersegment reassortments. These point to a high variability potential in WMV that may lead to the formation of strains with novel properties. These new data on WMV can promote better understanding of: ecological features of its circulation; relationships within the genus Orbivirus; and the medical significance of the virus.
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тезис
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Isolation and characterization of Wad Medani virus obtained in the tuva Republic of Russia
|
01.03.2021 |
Dedkov V.G.
Dolgova A.S.
Safonova M.V.
Samoilov A.E.
Belova O.A.
Kholodilov I.S.
Matsvay A.D.
Speranskaya A.S.
Khafizov K.
Karganova G.G.
|
Ticks and Tick-borne Diseases |
10.1016/j.ttbdis.2020.101612 |
0 |
Ссылка
© 2020 Elsevier GmbH Wad Medani virus (WMV) belongs to the genus Orbivirus and is a poorly studied arbovirus with unclear medical significance. Presently, a limited number of WMV strains are characterized and available in NCBI GenBank, some isolated many years ago. A new WMV strain was isolated in 2012 from Dermacentor nuttalli ticks collected from sheep in the Tuva Republic, Russia, and sequenced using high-throughput methods. Complete coding sequences were obtained revealing signs of multiple intersegment reassortments. These point to a high variability potential in WMV that may lead to the formation of strains with novel properties. These new data on WMV can promote better understanding of: ecological features of its circulation; relationships within the genus Orbivirus; and the medical significance of the virus.
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тезис
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Genetic diversity of Kemerovo virus and phylogenetic relationships within the Great Island virus genetic group
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01.03.2020 |
Safonova M.
Gmyl A.
Lukashev A.
Speranskaya A.
Neverov A.
Fedonin G.
Pimkina E.
Matsvay A.
Khafizov K.
Karganova G.
Kozlovskaya L.
Valdokhina A.
Bulanenko V.
Dedkov V.
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Ticks and Tick-borne Diseases |
10.1016/j.ttbdis.2019.101333 |
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Ссылка
© 2019 Elsevier GmbH Kemerovo virus (KEMV) is a member of the Great Island virus genetic group, belonging to the tick-borne arboviruses of the genus Orbivirus within the family Reoviridae. Nine strains of KEMV, which were isolated from various locations in Russia, were sequenced by high-throughput sequencing to study their intraspecific diversity and the interspecific relationships of viruses within the Great Island genetic group. For the first time, multiple reassortment within KEMV was reliably demonstrated. Different types of independently emerged alternative reading frames in segment 9 and heterogeneity of the viral population in one of the KEMV strains were found. The hypothesis of the role of an alternative open reading frame (ORF) in segment 9 in KEMV cellular tropism was not confirmed in this study.
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тезис
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Genetic diversity of Kemerovo virus and phylogenetic relationships within the Great Island virus genetic group
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01.03.2020 |
Safonova M.
Gmyl A.
Lukashev A.
Speranskaya A.
Neverov A.
Fedonin G.
Pimkina E.
Matsvay A.
Khafizov K.
Karganova G.
Kozlovskaya L.
Valdokhina A.
Bulanenko V.
Dedkov V.
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Ticks and Tick-borne Diseases |
10.1016/j.ttbdis.2019.101333 |
0 |
Ссылка
© 2019 Elsevier GmbH Kemerovo virus (KEMV) is a member of the Great Island virus genetic group, belonging to the tick-borne arboviruses of the genus Orbivirus within the family Reoviridae. Nine strains of KEMV, which were isolated from various locations in Russia, were sequenced by high-throughput sequencing to study their intraspecific diversity and the interspecific relationships of viruses within the Great Island genetic group. For the first time, multiple reassortment within KEMV was reliably demonstrated. Different types of independently emerged alternative reading frames in segment 9 and heterogeneity of the viral population in one of the KEMV strains were found. The hypothesis of the role of an alternative open reading frame (ORF) in segment 9 in KEMV cellular tropism was not confirmed in this study.
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тезис
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