Репозиторий Университета

Год публикации: Все года 2018 2019 2020

Название	Дата публикации	Коллектив авторов	Журнал	DOI	Индекс цитирования	Ссылка на источник
Dynamics of Renin, Angiotensin II, and Angiotensin (1–7) during Pregnancy and Predisposition to Hypertension-Associated Complications angiotensin(1–7) angiotensinII pregnancy renin renin—angiotensin—aldosteronesystem	01.08.2018	Khlestova G. Romanov A. Nizyaeva N. Karapetyan A. Baev O. Ivanets T.	Bulletin of Experimental Biology and Medicine		2	Ссылка © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Changes in the levels of rennin, angiotensin II, and angiotensin (1–7) were studied during normal pregnancy. The blood was taken on gestation days 140-237 and 238-280. No significant changes in renin concentration were observed during normal pregnancy (p=0.423). The level of angiotensin II increased during normal pregnancy from 9.7±1.2 to 14.7±1.9 pg/ml (p=0.019). On the contrary, angiotensin (1–7) concentration decreased from 771.1±44.2 to 390.7±13.9 pg/ml (p<0.001). The shift in the proportion between vasoconstrictor angiotensin II and vasodilaltor angiotensin (1–7) attests to high predisposition of pregnant women to hypertension-related complications. Читать тезис
Studies of the Association between the Kynurenine-3-Monooxygenase Gene and Depression depression gene inflammation kynurenine kynurenine-3-monooxygenase tryptophan	01.05.2018	Lezheiko T. Golimbet V. Andryushchenko A. Melik-Pashayan A. Mironova E.	Neuroscience and Behavioral Physiology		0	Ссылка © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Objective. To study the association between the kynurenine-3-monooxygenase (KMO) gene and depression. Materials and methods. Polymorphic loci rs2275163 (C/T) and rs1053230 (A/G) of the KMO gene were studied in patients with depression (study group) and mentally healthy subjects of comparable gender and age (control group). Results and conclusions. The rs2275163 polymorphism was not associated with depression. An association between the rs1053230 polymorphism and depression was found. The frequency of the GG genotype, linked with lower KMO activity and increased kynurenic acid levels in patients with endogenous psychoses, was greater in the study group than the control group (p = 0.001, OR 2.8 (95% CI 1.73–4.24). thus, the GG genotype can be regarded as a risk allele for developing depression. Читать тезис

Репозиторий Университета

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