Neuroprotectors in the correction of cognitive impairment
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01.01.2018 |
Shavlovskaya O.
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Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova |
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© 2018, Media Sphera Publishing Group. All rights reserved. The main groups of neuroprotectors, which are active in preventing the processes of the death of the nerve cells of vascular, traumatic, toxic and other etiologies and can decrease the severity of cognitive impairment, include phosphatidylcholine, phosphatidylserine, preparations based on ginkgo biloba, group B vitamins, folic acid. Preparations based on ginkgo biloba have the same effect as synthetic nootropics. The antioxidant and membrane-stabilizing effects of neuroprotectors are highlighted. In view of practical applications, attention is given to the advantages of the combinations of different neuroprotectors. Cerebrovin as one of these drugs can be recommended for treatment of cognitive impairment in the elderly.
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The endemicity of an area in terms of micronutrient deficiencies as a criterion for compounding a basic vitamin-mineral complex for the periconceptional period
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01.01.2018 |
Shikh E.
Makhova A.
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Akusherstvo i Ginekologiya (Russian Federation) |
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0 |
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© Bionika Media Ltd. The authors have carried out a systems analysis of the data available in the current literature on the effect of micronutrients, such as iodine, polyunsaturated fatty acids, folic acid, and vitamin D, on a woman’s reproductive health. Due to its geographical location, climatic features, and eating habits, our country has the proven deficiency of a number of micronutrients that play an important role in the periconceptional period. These micronutrients include iodine, polyunsaturated fatty acids, folic acid, and vitamin D. The content of micronutrients should not exceed the physiological daily requirement in the basic complexes intended for the prevention of deficiency, The excessive content of components can cause undesirable reactions and contribute to the allergization of newborns. In clinically pronounced deficiency, the basal complex can be combined with a monocomponent vitamin preparation for the targeted correction of vitamin and mineral status.
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Problems in the choice of a folate formulation for correction of folate status
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01.01.2018 |
Shikh E.
Makhova A.
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Akusherstvo i Ginekologiya (Russian Federation) |
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0 |
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© Bionika Media Ltd. A systems analysis of the data available in the literature on the problem of choosing the optimal folate formulation in order to correct folate status in obstetric and gynecologic practice was carried out. There is plenty of evidence that increasing the folate status reduces the risk of neonatal neural tube defects. Higher folate intake through supplementation with folic acid (FA) or 5-methyltetrahydrofolate (L-methyl-THF) is recommended during pregravid preparation and early pregnancy. L-5-methyl-THF has a number of advantages over FA, since it is a physiological compound and has greater bioavailability. 5-methyl-THF is also available as a crystalline form of calcium salt (metafolin) that has the stability required for use as a supplement. When correcting the folate status in obstetric and gynecological practice, it is recommended that a choice should be made in favor of a formulation that has the best bioavailability, as seen in metafolin.
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Assessment of the sufficiency of Moscow population with folic acid, depending on the combined effect of polymorphism of MTHFR and FTO genes
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01.01.2018 |
Sorokina E.
Pogozheva A.
Aristarkhova T.
Baturin A.
Tutelyan V.
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Voprosy Pitaniia |
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© 2018 Nutritec. All rights reserved. The results of assessing the sufficiency offolic acid of the residents of the Moscow region have been presented depending on rs1801133 MTHFRgene polymorphism and rs9939609 FTO gene polymorphism. A total of 326 people were examined, including 74 men and 252 women aged 20 to 65 years. The results of determining the level of folic acid in blood serum showed insufficiency of this vitamin among the population of the Moscow region of the Russian Federation. The expressed vitamin deficit (level <3,0 ng/ml) was detected in 24.2% of the surveyed residents, in 22.8% folic acid level was at the lower bound of the norm (3.0-4.5 ng/ml). The results of genotyping showed a statistically significant association of low folic acid level with rs1801133 MTHFR gene polymorphism in carriers of A allele of rs9939609 FTO gene polymorphism both in the homozygous state (genotype AA) and in the heterozygous (genotype AT) state, OR=4.26; CI (1.40-12.9), p=0.008, as well as with rs9939609 FTO gene polymorphism in carriers of the T allele of rs1801133 MTHFR gene polymorphism both in the homozygous (genotype TT) and heterozygous (CTgenotype) state, OR-3.29; CI (1.07-10.1), p=0.03. In carriers of 3 alleles of risk offolic acid deficiency [rs9939609 FTO gene polymorphism and rs1801133 MTHFR gene polymorphism (genotypes CT/AA and TT/AT)] blood serum level of folic acid was below the norm, that indicated folate deficiency in this category of persons.
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