Год публикации:
Все года
2018
2019
2020
Название |
Дата публикации |
Коллектив авторов |
Журнал |
DOI |
Индекс цитирования |
Ссылка на источник |
Evaluation of the Efficiency of Lytic Mycobacteriophage D29 on the Model of M. tuberculosis-Infected Macrophage RAW 264 Cell Line
|
01.01.2018 |
Lapenkova M.
Smirnova N.
Rutkevich P.
Vladimirsky M.
|
Bulletin of Experimental Biology and Medicine |
|
1 |
Ссылка
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Culture of mouse macrophages (RAW 264.7 ATCC strain) in wells of a 6-well plate was infected with M. tuberculosis in proportion of 15 mycobacteria per one macrophage and then treated with a lytic strain of mycobacteriophage D29. Antibacterial efficacy of mycobacteriophages was studied using D29 phage (activity 108 plaque-forming units/ml) previously purified by ion exchange chromatography. After single and double 24-h treatment, the lysed cultures of macrophages were inoculated onto Middlebrook 7H10 agar medium. The number of mycobacterial colonies in control and test wells (at least 3 wells in each group) was 300.178±12.500 and 36.0±5.4, respectively (p<0.01).
Читать
тезис
|
New strategies and molecular targets for antimicrobial preparations of the next generation
|
01.01.2018 |
Kareva E.
Serebrova S.
Lazareva N.
Shipilova S.
Bulgakova V.
Kozaeva L.
Kononova I.
Yarovoi S.
Drozdov V.
Starodubtsev A.
|
Eksperimental'naya i Klinicheskaya Farmakologiya |
|
0 |
Ссылка
© 2018 Ruslania. All rights reserved. The frequency of resistance of pathogens to antimicrobial drugs is on continued rise with a threat of returning to the "pre-antibiotic" era. This has led to the appearance of bacterial infections which are essentially untreatable by the current spectrum of available modem preparations. The presence of cross-group resistance inspires the search of new targets for antibacterial drugs both in the pathogen body and in the human body. This review considers potential strategies for the search of the new generation of antimicrobial agents for treating drug-resistant pathogens.
Читать
тезис
|