Репозиторий Университета

© 2018 Dynasty Publishing House. All rights reserved. A systematic review substantiates the significance of mutual influence and interaction between infection pathogens, humoral and cell-mediated innate immunity that condition triggering or termination of infectious process, its prodromal period, severity of clinical manifestations and outcomes of urogenital infections in pregnant women. The determining factor is the result of TLRs response to microbial patterns taking into account the preparedness and state of innate immune receptors. The latter might ensure a higher anti-infection resistance to the pathogen up to termination of disease, or to promote the development of infectious process with marked inflammatory reaction, or to make the infectious process chronic up to damaging the tissue cells of the macroorganism. The understanding of the mechanisms of natural anti-infectious resistance and enhanced sensitivity and susceptibility to infectious agents has been objectified. TLRs act as molecular genetic markers of anti-infection resistance of the body and its state of health.

© 2018 Dynasty Publishing House. All rights reserved. The systematic review provides a justification for the value of innate immunity as an initial, necessary and determinant stage in the development of adaptive immunity. The participation of TLRs as a leading component of PRRs-system in maintaining natural congenital anti-infection resistance and homeostasis of the organism, in launching and dynamics of development of adaptive immunity to pathogens of infectious and non-infectious genesis was studied in detail. The importance of the influence of these pathogens on the homeostasis of the organism, on the formation of disturbances in anti-infective resistance at the organism and local levels, revealing new pathophysiological and immunological pathogenetic mechanisms of the development of these pathological processes is established. The colossal gap between fundamental studies of the biology and morphology of microorganisms and clinical studies of the diseases they cause is shortening. In an accessible form, explanations are provided for the absence of symptoms, the possibility of atypical manifestations, and the asymptomatic course of infection. There are new wide opportunities to improve and enhance the information content and personalization methods of diagnosis, treatment and prevention, as well as the creation of pharmaceuticals that act detrimental to all forms of cycle of development of pathogens, and new immunomodulatory drugs for the most effective treatment and prevention of diseases.