Репозиторий Университета

Recently, zinc and its alloys have been proposed as promising candidates for biodegradable metals (BMs), owning to their preferable corrosion behavior and acceptable biocompatibility in cardiovascular, bone and gastrointestinal environments, together with Mg-based and Fe-based BMs. However, there is the desire for surface treatment for Zn-based BMs to better control their biodegradation behavior. Firstly, the implantation of some Zn-based BMs in cardiovascular environment exhibited intimal activation with mild inflammation. Secondly, for orthopedic applications, the biodegradation rates of Zn-based BMs are relatively slow, resulting in a long-term retention after fulfilling their mission. Meanwhile, excessive Zn2+ release during degradation will cause in vitro cytotoxicity and in vivo delayed osseointegration. In this review, we firstly summarized the current surface modification methods of Zn-based alloys for the industrial applications. Then we comprehensively summarized the recent progress of biomedical bulk Zn-based BMs as well as the corresponding surface modification strategies. Last but not least, the future perspectives towards the design of surface bio-functionalized coatings on Zn-based BMs for orthopedic and cardiovascular applications were also briefly proposed.

Recently, zinc and its alloys have been proposed as promising candidates for biodegradable metals (BMs), owning to their preferable corrosion behavior and acceptable biocompatibility in cardiovascular, bone and gastrointestinal environments, together with Mg-based and Fe-based BMs. However, there is the desire for surface treatment for Zn-based BMs to better control their biodegradation behavior. Firstly, the implantation of some Zn-based BMs in cardiovascular environment exhibited intimal activation with mild inflammation. Secondly, for orthopedic applications, the biodegradation rates of Zn-based BMs are relatively slow, resulting in a long-term retention after fulfilling their mission. Meanwhile, excessive Zn2+ release during degradation will cause in vitro cytotoxicity and in vivo delayed osseointegration. In this review, we firstly summarized the current surface modification methods of Zn-based alloys for the industrial applications. Then we comprehensively summarized the recent progress of biomedical bulk Zn-based BMs as well as the corresponding surface modification strategies. Last but not least, the future perspectives towards the design of surface bio-functionalized coatings on Zn-based BMs for orthopedic and cardiovascular applications were also briefly proposed.

© 2019 Wiley Periodicals, Inc. Background: Clinical measures and implant design innovation to improve primary osseointegration and reduce the bacterial contamination of the peri-implant area are intended to reduce the incidence of late inflammatory complications in dental implantation. Purpose: To study the effect of nanostructured coating and antiseptic sealant on the outcomes of dental implantation. Materials and methods: Ninety-six individuals were clinically supervised. In the first group (Screw Ti + sealant), a special antiseptic sealant matrix was used; the same sealant was used with nanocoated implants in the second group (Nanocoat + sealant), and the conventional treatment protocol was used in the control group (Screw Ti). Patients were evaluated longitudinally during treatment and rehabilitation phases with clinical examinations, radiography, periodontal pathogen detection, and patient experience surveys. Results: For patients who received a nanocoated implant and an antiseptic sealant (Nanocoat + sealant), relatively better hygienic indices were observed; there was less contamination with periodontal pathogens, bone density remained at the required level, and the overall results of treatment were better. Conclusions: Using a matrix for sealing the dental implant-abutment interface with a nanostructured surface provides reliable results regarding stable osseointegration and clinical and patient-reported outcomes of treatment success.