Репозиторий Университета

© 2019, © 2019 Informa UK Limited, trading as Taylor  &  Francis Group. Introduction: Due to the polymorphic clinical presentations and manifestations of systemic lupus erythematosus (SLE), biomarkers with enough diagnostic and prognostic value are of paramount importance. Recently, anti-double stranded DNA (anti-dsDNA) auto-antibodies have been proposed to monitor the response to different therapies. It has also been suggested that they should be employed as entry markers in trial studies. However, their clinical use remains still debated and, sometimes, controversial, due to conflicting findings reported. Areas covered: Through an extensive literature review, we evaluated changes in anti-dsDNA auto-antibodies levels before and after the administration of the treatment (either biological or non-biological). Expert opinion: Anti-dsDNA auto-antibodies related findings are still difficult to compare mainly because of the different detecting methods employed, even though in most studies included in this review a consistent decreasing pattern after the treatment seems to emerge. Hence, if properly standardized, anti-dsDNA auto-antibody profile may be a reliable biomarker to monitor the effectiveness of biologics as well as of non-biological drugs, especially if grouped in composite outcomes scores, such as the ‘Lupus Multivariable Outcome Score’ (LUMOS) or measured with other biomarkers, such as anti-nucleosome auto-antibodies. We recommend the assessment of anti-dsDNA auto-antibodies levels in both daily practice and research settings.

© 2018 Stavropol State Medical University. All Rights Reserved. Type I Diabetes mellitus (DM), or insulin-dependent diabetes, is the most common endocrine pathology among children and teenagers. The purpose of this study is to research the content of 1A melatonin receptor and antibodies to it in blood serum of children and teenagers. We examined 71 children and teenagers aged 1.9 to 17 years. We measured the content of 1A melatonin receptor and antibodies to it in hemolymph using an immunofluorescence assay test system (IFA). We found that the lowest levels of the 1A melatonin receptor were prevailing in children with a serious condition at the DM decompensation stage, median values were diagnosed in children in a state of moderate severity, and the maximum quantities are fixed in children against the background of the compensation of DM. The obtained data confirm the hypothesis about the possible involvement of the corpus pineale (epiphysis) in the pathogenesis of Type I Diabetes mellitus.