Тема НИР

   

Разработка экспериментальных и клинических методов оценки фармакологической активности лекарственных средств и их лекарственных форм как основа для получения новых знаний в подготовке провизоров

 

Цели и задачи

     Целью НИР является подготовка высококвалифицированных специалистов-провизоров с учетом требований современной фармацевтической отрасли. 


     Задачи:

     1.      Изучение передового международного опыта в области поиска и разработки экспериментальных и клинических методов оценки фармакологической активности лекарственных средств и их лекарственных форм с целью внедрения в практику российских фармацевтических предприятий и научно-исследовательских центров.

     2.      Развитие междисциплинарных знаний, позволяющих проводить исследования на стыке наук. 

     3.      Создание баз практики на фармацевтических предприятиях.

     4.      Привлечение работодателей для участия в образовательном процессе, аттестации и аккредитации выпускников.

 

Актуальность


 

Результаты

Наиболее значимые публикации 2019-2021 (Q1)


  1. WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia /Thomson MN, Cuevas CA, Bewarder TM, Dittmayer C, Miller LN, Si J, Cornelius RJ, Su XT, Yang CL, McCormick JA, Hadchouel J, Ellison DH, Bachmann S, Mutig K. Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F216-F228. doi: 10.1152/ajprenal.00232.2019. Epub 2019 Nov 18. PMID: 31736353; PMCID: PMC6985824.

  2. Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target /Sukocheva OA, Furuya H, Ng ML, Friedemann M, Menschikowski M, Tarasov VV, Chubarev VN, Klochkov SG, Neganova ME, Mangoni AA, Aliev G, Bishayee A. Pharmacol Ther. 2020 Mar;207:107464. doi: 10.1016/j.pharmthera.2019.107464. Epub 2019 Dec 18. PMID: 31863815.

  3. Alterations of Astrocytes in the Context of Schizophrenic Dementia /Tarasov VV, Svistunov AA, Chubarev VN, Sologova SS, Mukhortova P, Levushkin D, Somasundaram SG, Kirkland CE, Bachurin SO, Aliev G. Front Pharmacol. 2020 Feb 7;10:1612. doi: 10.3389/fphar.2019.01612. PMID: 32116664; PMCID: PMC7020441.

  4. Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney /Ostroverkhova DS, Hu J, Tarasov VV, Melnikova TI, Porozov YB, Mutig K. Cells. 2020 Jul 9;9(7):1644. doi: 10.3390/cells9071644. PMID: 32659887; PMCID: PMC7407487.

  5. Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response /Mikhaylenko DS, Nemtsova MV, Bure IV, Kuznetsova EB, Alekseeva EA, Tarasov VV, Lukashev AN, Beloukhova MI, Deviatkin AA, Zamyatnin AA Jr. Int J Mol Sci. 2020 Jul 11;21(14):4911. doi: 10.3390/ijms21144911. PMID: 32664585; PMCID: PMC7402327.

  6. Publisher Correction: Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities /Rayavarapu S, Yarla NS, Kadiri SK, Bishayee A, Vidavalur S, Tadikonda R, Basha M, Pidugu VR, Dowluru KSVGK, Lakappa DB, Kamal MA, Ashraf GM, Tarasov VV, Chubarev VN, Klochkov SG, Barreto GE, Bachurin SO, Aliev G. Sci Rep. 2020 Jan 8;10(1):185. doi: 10.1038/s41598-019-57392-w. Erratum for: Sci Rep. 2017 Aug 16;7(1):8309. PMID: 31913323; PMCID: PMC6949224.

  7. Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions /Bondarev AD, Attwood MM, Jonsson J, Chubarev VN, Tarasov VV, Schiöth HB. Expert Opin Drug Discov. 2020 Nov;15(11):1291-1307. doi: 10.1080/17460441.2020.1791075. Epub 2020 Jul 10. PMID: 32648789.

  8. Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy /Deviatkin AA, Vakulenko YA, Akhmadishina LV, Tarasov VV, Beloukhova MI, Zamyatnin AA Jr, Lukashev AN. Biomedicines. 2020 Jan 9;8(1):9. doi: 10.3390/biomedicines8010009. PMID: 31936504; PMCID: PMC7168286.

  9. Production of biomedical cell products: requirements for the quality of donor material and excipients of animal origin (review) /Vodiakova MA, Sayfutdinova AR, Melnikova EV, Goryaev AA, Sadchikova NP, Gegechkori VI, Merkulov VA. RSC Med Chem. 2020 Feb 19;11(3):349-357. doi: 10.1039/c9md00529c. PMID: 33479640; PMCID: PMC7580781.

  10. Medical education state reform in Tajikistan: Between tradition and modernity /Zavadskiy SP, Yefimova AM. Med Teach. 2020 Aug;42(8):861-870. doi: 10.1080/0142159X.2020.1767284. Epub 2020 Jun 1. PMID: 32476521.

  11. Analysis of miRNA Expression in Patients with Rheumatoid Arthritis during Olokizumab Treatment /Bure IV, Mikhaylenko DS, Kuznetsova EB, Alekseeva EA, Bondareva KI, Kalinkin AI, Lukashev AN, Tarasov VV, Zamyatnin AA Jr, Nemtsova MV. J Pers Med. 2020 Oct 31;10(4):205. doi: 10.3390/jpm10040205. PMID: 33142700; PMCID: PMC7712090.

  12. Angiotensin II receptor blockade alleviates calcineurin inhibitor nephrotoxicity by restoring cyclooxygenase 2 expression in kidney cortex /Hu J, Xu Y, Bachmann S, Mutig K. Acta Physiol (Oxf). 2021 May;232(1):e13612. doi: 10.1111/apha.13612. Epub 2021 Jan 18. PMID: 33377278.

  13. Extracellular vesicles in cancer nanomedicine /Tarasov VV, Svistunov AA, Chubarev VN, Dostdar SA, Sokolov AV, Brzecka A, Sukocheva O, Neganova ME, Klochkov SG, Somasundaram SG, Kirkland CE, Aliev G. Semin Cancer Biol. 2021 Feb;69:212-225. doi: 10.1016/j.semcancer.2019.08.017. Epub 2019 Aug 14. PMID: 31421263.

  14. High efcacy of onabotulinumtoxinA treatment in patients with comorbid migraine and depression: a meta-analysis /Affatato O, Moulin TC, Pisanu C, Babasieva VS, Russo M, Aydinlar EI, Torelli P, Chubarev VN, Tarasov VV, Schiöth HB, Mwinyi J. J Transl Med. 2021 Mar 31;19(1):133. doi: 10.1186/s12967-021-02801-w. PMID: 33789668; PMCID: PMC8011097.

  15. Short- and medium-term exposures of diazepam induce metabolomic alterations associated with the serotonergic, dopaminergic, adrenergic and aspartic acid neurotransmitter systems in zebrafish (Danio rerio) embryos/larvae /Markin PA, Brito A, Moskaleva NE, Tagliaro F, Tarasov VV, La Frano MR, Savitskii MV, Appolonova SA. Comp Biochem Physiol Part D Genomics Proteomics. 2021 Jun;38:100816. doi: 10.1016/j.cbd.2021.100816. Epub 2021 Feb 16. PMID: 33610025.

  16. Recent developments of HDAC inhibitors: Emerging indications and novel molecules /Bondarev AD, Attwood MM, Jonsson J, Chubarev VN, Tarasov VV, Schiöth HB. Br J Clin Pharmacol. 2021 May 10. doi: 10.1111/bcp.14889. Epub ahead of print. PMID: 33971031.

  17. Predictive biomarkers for systemic therapy of hepatocellular carcinoma /Moldogazieva NT, Zavadskiy SP, Sologova SS, Mokhosoev IM, Terentiev AA. Expert Rev Mol Diagn. 2021 Oct 12:1-18. doi: 10.1080/14737159.2021.1987217. Epub ahead of print. PMID: 34582293.

  18. Increased Oxidative Stress in the Prefrontal Cortex as a Shared Feature of Depressive- and PTSD-Like Syndromes: Effects of a Standardized Herbal Antioxidant /de Munter J, Pavlov D, Gorlova A, Sicker M, Proshin A, Kalueff AV, Svistunov A, Kiselev D, Nedorubov A, Morozov S, Umriukhin A, Lesch KP, Strekalova T, Schroeter CA. Front Nutr. 2021 Apr 15;8:661455. doi: 10.3389/fnut.2021.661455. PMID: 33937310; PMCID: PMC8086427.

  19. Pharmacological treatment of migraine: Drug classes, mechanisms of action, clinical trials and new treatments /Zobdeh F, Ben Kraiem A, Attwood MM, Chubarev VN, Tarasov VV, Schiöth HB, Mwinyi J. Br J Pharmacol. 2021 Dec;178(23):4588-4607. doi: 10.1111/bph.15657. Epub 2021 Sep 26. PMID: 34379793.

  20. AVIFAVIR for Treatment of Patients With Moderate Coronavirus Disease 2019 (COVID-19): Interim Results of a Phase II/III Multicenter Randomized Clinical Trial /Ivashchenko AA, Dmitriev KA, Vostokova NV, Azarova VN, Blinow AA, Egorova AN, Gordeev IG, Ilin AP, Karapetian RN, Kravchenko DV, Lomakin NV, Merkulova EA, Papazova NA, Pavlikova EP, Savchuk NP, Simakina EN, Sitdekov TA, Smolyarchuk EA, Tikhomolova EG, Yakubova EV, Ivachtchenko AV. Clin Infect Dis. 2021 Aug 2;73(3):531-534. doi: 10.1093/cid/ciaa1176. PMID: 32770240; PMCID: PMC7454388.

  21. The efficacy and safety of levilimab in severely ill COVID-19 patients not requiring mechanical ventilation: results of a multicenter randomized double-blind placebo-controlled phase III CORONA clinical study /Lomakin NV, Bakirov BA, Protsenko DN, Mazurov VI, Musaev GH, Moiseeva OM, Pasechnik ES, Popov VV, Smolyarchuk EA, Gordeev IG, Gilyarov MY, Fomina DS, Seleznev AI, Linkova YN, Dokukina EA, Eremeeva AV, Pukhtinskaia PS, Morozova MA, Zinkina-Orikhan AV, Lutckii AA. Inflamm Res. 2021 Dec;70(10-12):1233-1246. doi: 10.1007/s00011-021-01507-5. Epub 2021 Sep 29. PMID: 34586459; PMCID: PMC8479713.

  22. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia /Logunov DY, Dolzhikova IV, Shcheblyakov DV, Tukhvatulin AI, Zubkova OV, Dzharullaeva AS, Kovyrshina AV, Lubenets NL, Grousova DM, Erokhova AS, Botikov AG, Izhaeva FM, Popova O, Ozharovskaya TA, Esmagambetov IB, Favorskaya IA, Zrelkin DI, Voronina DV, Shcherbinin DN, Semikhin AS, Simakova YV, Tokarskaya EA, Egorova DA, Shmarov MM, Nikitenko NA, Gushchin VA, Smolyarchuk EA, Zyryanov SK, Borisevich SV, Naroditsky BS, Gintsburg AL; Gam-COVID-Vac Vaccine Trial Group. Lancet. 2021 Feb 20;397(10275):671-681. doi: 10.1016/S0140-6736(21)00234-8. Epub 2021 Feb 2. Erratum in: Lancet. 2021 Feb 20;397(10275):670. PMID: 33545094; PMCID: PMC7852454.

  23. Maintenance of glycaemic control with liraglutide versus oral antidiabetic drugs as add-on therapies in patients with type 2 diabetes uncontrolled with metformin alone: A randomized clinical trial in primary care (LIRA-PRIME) /Unger J, Allison DC, Kaltoft M, Lakkole K, Panda JK, Ramesh C, Sargin M, Smolyarchuk E, Twine M, Wolthers B, Yarimbas G, Zoghbi M; LIRA-PRIME investigators. Diabetes Obes Metab. 2021 Oct 7. doi: 10.1111/dom.14566. Epub ahead of print. PMID: 34622567.

  24. Past, present, and future of allergen immunotherapy vaccines /Dorofeeva Y, Shilovskiy I, Tulaeva I, Focke-Tejkl M, Flicker S, Kudlay D, Khaitov M, Karsonova A, Riabova K, Karaulov A, Khanferyan R, Pickl WF, Wekerle T, Valenta R. Allergy. 2021 Jan;76(1):131-149. doi: 10.1111/all.14300. Epub 2020 Apr 29. PMID: 32249442; PMCID: PMC7818275.


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