Репозиторий Университета

Salvage surgery for recurrent larynx cancer

  • Mimica X.
  • Hanson M.
  • Patel S.
  • McGill M.
  • McBride S.
  • Lee N.
  • Dunn L.
  • Cracchiolo J.
  • Shah J.
  • Wong R.
  • Ganly I.
  • Cohen M.
Дата публикации:01.11.2019
Журнал: Head and Neck
Ссылка: SCOPUS
Индекс цитирования: 1


© 2019 Wiley Periodicals, Inc. Background: Despite advances in treatment, the recurrence rates for laryngeal cancer range from 16% to 40%. Methods: Patients with recurrent laryngeal cancer treated at Memorial Sloan Kettering (MSK) from 1999 to 2016 were reviewed. Survival outcomes were analyzed. Results: Of 241 patients, 88% were male; the median age was 67 years; 71% had primary glottic tumors. At initial treatment, 72% of patients were seen with early stage disease; primary treatment was radiation (68%), chemoradiation (29%), and surgery (3%). The most common salvage surgery was total laryngectomy (74%). Forty-seven percentage were upstaged at salvage surgery. The 2- and 5-year disease-specific survival (DSS) was 74% and 57%, respectively. Patients with cT4 disease treated with nonsurgical primary management had a 0% 5-year DSS. Independent predictors of DSS were tumor location, perineural invasion, margin, and stage. Conclusions: Salvage surgery results in acceptable oncologic outcomes. Stage, disease site, perineural invasion, and margins are associated with inferior DSS.

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