Аннтотация

© 2018 Izdatel'stvo Meditsina. All rights reserved. We have studied the adaptogenic properties of Kardecaim phytopreparation based on dry extracts derived from Inula helenium L., Zingiber officinale Roscoe, Elletaria cardamomum (L.) Maton., and Caragaha spinose (L.) Wall, ex Homem, which contain phenolic compounds and terpenoids. A course of preventive administration of Kardecaim to white rats in a dose of 100 mg/kg for 7 days before the induction of acute emotional stress produced stress-protective effect by preventing the development of catabolic signs of Selye's triad in animal inner organs, including the thymus involution (40% lower than in control); degree of hemorrhagic and ulcerative defects in the stomach mucosa (5 times less than reference gastroprotector effect), and somewhat less pronounced effect on the stress-induced hypertrophy of adrenal glands, yet comparable to the effect of reference preparation (eleutherococcus extract). It was shown that the increase in the resistance to stress under the action of Kardecaim was due to the activation of synthesis of heat shock proteins (Hsp). The Hsp-70 content in the thymus of white rats undergoing emotional stress was 56% higher than in the control. The introduction of Kardecaim to intact animals had no effect on the basal level of Hsp-70. It was established that the expression of Hsp under the drug action was not connected with NO system, since the administration of Kardecaim on the background of stress impact was followed by a decrease in the NO metabolite yield.