Репозиторий Университета

Specific features of collagen implant biodegradation after glaucoma surgery in rabbit eye (experimental study)

  • Mamikonyan V.
  • Fisenko N.
  • Demura T.
  • Kogan E.
  • Kazaryan E.
Дата публикации:01.01.2018
Журнал: Eksperimental'naya i Klinicheskaya Farmakologiya
БД: Scopus
Ссылка: Scopus


© 2018 Izdatel'stvo Meditsina. All rights reserved. The healing process in the adult rabbit conjunctiva and sclera tissues after translimbal microdrainage with the use of either biodegradable antiglaucomatous drainage (BDAD) or iGen was studied. Wound areas showed similar acute inflammatory response to the implantation of both matrixes on the 7th day. Complete lysis degradation of iGen and BDAD was observed on 30th day and 60th day, respectively. Within 60 - 90 days after BDAD implantation, the wound areas of conjunctiva and sclera showed intensive angiogenesis and poor extracellular matrix scarring. In contrast, on the 90th day after iGen implantation, a decrease in angiogenesis and intensive extracellular matrix scar formation were observed. As a result of scarring the thin-walled vessels were compressed, which led to the reduction of aqueous humor outflow.

Вернуться назад