Репозиторий Университета

Differences between cerebrovascular effects of 5-hydroxyadamantane-2-one, nimodipine and S-amlodipine nicotinate in the hemorrhagic and ischemic model damage of rat brain


  • Mirzoyan R.
  • Gan'shina T.
  • Kim G.
  • Kurdyumov I.
  • Maslennikov D.
  • Kurza E.
  • Gorbunov A.
Дата публикации:01.01.2018
Журнал: Eksperimental'naya i Klinicheskaya Farmakologiya
БД: Scopus
Ссылка: Scopus
Индекс цитирования: 1

Аннтотация

© 2018 Izdatel'stvo Meditsina. All rights reserved. The cerebrovascular effects of 5-hydroxyadamantane-2-one (100 mg/kg, i.v.), nimodipine (0.03 mg/kg, i.v.), and S-amlodi- pine nicotinate (0.1 rag/kg, i.v.) were compared and found to differ significantly. While G ABA-ergic 5-hydroxyadaman- tan-2-one and slow calcium channels blocker nimodipine cause a pronounced increase in cerebral blood supply under conditions of global transient ischemia of the brain, their activity in modeling hemorrhagic stroke is significantly lower. At the same time, S-amlodipine nicotinate equally improves cerebral circulation in both hemorrhagic and ischemic brain damage, i.e., the cerebrovascular effect of S-amlodipine nicotinate in the hemorrhagic stroke model is superior to that of nimodipine and 5-hydroxyadamantan-2-one. This is due to a distinguishing feature of the of S-amlodipine nicotinate action, which, in contrast to 5-hydroxyadamantan-2-one and nimodipine, has a binary vasodilating effect on cerebral vessels: (i) blocking slow calcium channels and (ii) stimulating GABAA-receptors.


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