Regenerative potential of biodegradable collagen matrix for healing full-thickness defect of conjunctiva in rabbits


  • Demura T.
  • Fisenko N.
  • Mamikonyan V.
  • Kogan E.
  • Avetisov S.
Дата публикации:01.01.2018
Журнал: Eksperimental'naya i Klinicheskaya Farmakologiya
БД: Scopus
Ссылка: Scopus

Аннтотация

© 2018 American Leather Chemists Association. All rights reserved. The regenerative potential of biodegradable collagen matrix (hemostatic sponge) for healing full-thickness rabbit conjunctival injury was studied. Results of histological investigation and scanning electron microscopy showed evidence of the progressive degradation of collagen matrix followed by granulation tissue formation from periphery to the center of the conjunctival wound. The ungrafted conjunctival defect was substituted with granulation tissue from the intact edges of wound to the center. Both matrix-grafted and ungrafted full-thickness conjunctival defects were covered completely with loose stroma and stratified squamous epithelium within 30 days. Thus, high regenerative potential of biodegradable collagen matrix (hemostatic sponge) implanted into the zone of injury for healing full-thickness defect of rabbit conjunctiva was established.


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