Репозиторий Университета

The role of pathogens and innate immune factors in the pathogenesis of urogenital infection in pregnant women

  • Karaulov A.
  • Afanas'ev S.
  • Aleshkin V.
  • Bondarenko N.
  • Voropaeva E.
  • Afanas'ev M.
  • Nesvizhskiy Y.
  • Borisova O.
  • Aleshkin A.
  • Urban Y.
  • Bochkareva S.
  • Borisova A.
  • Voropaev A.
Дата публикации:01.01.2018
Журнал: Voprosy Ginekologii, Akusherstva i Perinatologii
БД: Scopus
Ссылка: Scopus


© 2018 Dynasty Publishing House. All rights reserved. A systematic review substantiates the significance of mutual influence and interaction between infection pathogens, humoral and cell-mediated innate immunity that condition triggering or termination of infectious process, its prodromal period, severity of clinical manifestations and outcomes of urogenital infections in pregnant women. The determining factor is the result of TLRs response to microbial patterns taking into account the preparedness and state of innate immune receptors. The latter might ensure a higher anti-infection resistance to the pathogen up to termination of disease, or to promote the development of infectious process with marked inflammatory reaction, or to make the infectious process chronic up to damaging the tissue cells of the macroorganism. The understanding of the mechanisms of natural anti-infectious resistance and enhanced sensitivity and susceptibility to infectious agents has been objectified. TLRs act as molecular genetic markers of anti-infection resistance of the body and its state of health.

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