Eng

The anemonia viridis venom: Coupling biochemical purification and rna-seq for translational research


  • Nicosia A.
  • Mikov A.
  • Cammarata M.
  • Colombo P.
  • Andreev Y.
  • Kozlov S.
  • Cuttitta A.
Дата публикации:25.10.2018
Журнал: Marine Drugs
БД: Scopus
Ссылка: Scopus

Аннтотация

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license Blue biotechnologies implement marine bio-resources for addressing practical concerns. The isolation of biologically active molecules from marine animals is one of the main ways this field develops. Strikingly, cnidaria are considered as sustainable resources for this purpose, as they possess unique cells for attack and protection, producing an articulated cocktail of bioactive substances. The Mediterranean sea anemone Anemonia viridis has been studied extensively for years. In this short review, we summarize advances in bioprospecting of the A. viridis toxin arsenal. A. viridis RNA datasets and toxin data mining approaches are briefly described. Analysis reveals the major pool of neurotoxins of A. viridis, which are particularly active on sodium and potassium channels. This review therefore integrates progress in both RNA-Seq based and biochemical-based bioprospecting of A. viridis toxins for biotechnological exploitation.


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