Репозиторий Университета

Late-life depression and alzheimer disease: A potential synergy of the underlying mechanisms


  • Leszek J.
  • Trypka E.
  • Koutsouraki E.
  • Michmizos D.
  • Yarla N.
  • Tarasov V.
  • Ashraf G.
  • Aliev G.
Дата публикации:01.01.2018
Журнал: Current Medicinal Chemistry
БД: Scopus
Ссылка: Scopus
Индекс цитирования: 2

Аннтотация

© 2018 Bentham Science Publishers. A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.


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