Репозиторий Университета

The role of neurosteroids metabolism in anticompulsive effect of pyrazole[c]pyridine derivative gizh-72


  • Kudryashov N.
  • Kalinina T.
  • Kasabov K.
  • Shimshirt A.
  • Volkova A.
  • Zhmurenko L.
  • Voronina T.
Дата публикации:01.01.2018
Журнал: Eksperimental'naya i Klinicheskaya Farmakologiya
БД: Scopus
Ссылка: Scopus

Аннтотация

© 2018 Izdatel'stvo Meditsina. All rights reserved. There were studied the impact of selective antagonist of the mitochondrial translocator protein (TSPO 18 kDa) PK11195 (N-butan-2-yl-l-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; 1 or 3 mg/kg, i.p.) and 5α-reductase inhibitor finasteride (1.25; 2.5; 5 mg/kg, i.p.) on anticonvulsive effect of pyrazole[c]pyridine derivative GIZH-72 (4,6-dimethyl-2-(4-chlorophenyl)-2,3-dihydro-l//-pyrazolo[4,3-c]pyridin-3-one chloralhydrate, 20 mg/kg, i.p.) in marble burying test in C57BL/6 mice. It is established that PK11195 (1 or 3 mg/kg, i.p.) had no effects on both compulsive behavior of mice and anticompulsive effect of GIZH-72 (20 mg/kg, i.p.). Finasteride (2.5 or 5.0 mg/kg) decreased of compulsive behavior in the dose-dependent manner in C57BL/6 mice. Pretreatment with finasteride (2.5 or 5.0 mg/kg, i.p.) led to completely reduction of anticompulsive effect of GIZH-72 (20 mg/kg, i.p.). Thus, anticompulsive effect of GIZH-72 may depend on activity of 5α-reductase, but not TSPO 18 kDa.


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