Аннтотация

© 2018 Izdatel'stvo Meditsina. All rights reserved. This research was aimed at the pharmacological analysis of dermotropic activity ofCaragana jubata (Pall.) poiraqueous extract on the model of atopic contact dermatitis induced by 2,4-dinitrochlorobenzene in male rats. It was found that the aqueous C. jubata extract exhibited expressed dermotropic activity as manifested by reducing thickness of the skin fold by 47% (p = 0.05) and decreasing severity of the onset of contact dermatitis on the average by 38% (p = 0.05). Histological examination showed positive trends in the regeneration of skin lesion. Hematologic examination showed normalization of peripheral blood parameters in animals affected by contact dermatitis. Calculations of the index of inhibition of the inflammatory response confirmed anti-inflammatory effect of the aqueous C. jubata extract.