Аннтотация

© 2018, Pediatria Ltd. All rights reserved. It is known that duration of postvaccinal immunity against viral hepatitis B is influenced by such factors as time of the last vaccination, immunization schedule, age, profession, the initial health state. Often there are difficulties in vaccinating children with recurrent respiratory diseases (RRD). Objective of the research – to evaluate the peculiarities of specific immunityformation after hepatitis B vaccination in children with RRD. Study materials and methods: authors performed a comparative prospective study to assess the level of postvaccinal immunity against viral hepatitis B in two comparison groups – healthy children and children with RRD aged 1–17 years. Blood was sampled for evaluation of anti-HBs and a protective level of protection for 18 months from the start of vaccination. Results: children with RRD had a delayed synthesis of antibodies for administration of hepatitis B vaccine first doses. The 3rd vaccine administration results in 100% seroconversion. One year after complete vaccination a marked decrease in anti-HBs occurs in such children, and the proportion of seronegative individuals among them is 40% compared to 10% among healthy individuals.