Аннтотация

© 2018, Pediatria Ltd. All rights reserved. Modern literature data suggest that the active metabolite of vitamin D 1,25 (OH)2D is a steroid hormone with an extremely wide range of biological effects. Its role in the body is not limited to the regulation of calcium homeostasis. It has antiproliferative and differentiating effects, immunomodulatory and anti-inflammatory effects, promotes the synthesis and secretion of insulin, affects the functions of the cardiovascular, muscular and nervous system, the state of fat and connective tissue, etc. Vitamin D has many targets and is involved in a variety of physiological processes, which is why its potential role as a risk factor for development or, on the contrary, a protector in a variety of diseases incl. rheumatic (RD), is actively studied. Elimination of vitamin D insufficiency/deficiency should be considered an important aspect of treatment of patients with RD, as this can decrease not only the activity of autoimmune processes and inflammation, but also the risk of comorbid pathology, incl. fractures, obesity, cardiovascular pathology, disorders of carbohydrate metabolism, secondary infection, including tuberculosis, etc. Children with various RD often have vitamin D insufficiency/deficiency, and for this patient group its timely detection and elimination is particularly important. Further studies are needed to develop coordinated recommendations for monitoring vitamin D sufficiency and the use of its various metabolites in the complex treatment of children with rheumatic spectrum diseases.