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Bilayer permeability during phase transition as an Erlang flow of hydrophilic pores resulting from diffusion in the radius space
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Аносов Андрей Анатольевич
Смирнова Елена Юрьевна
Несвижский Юрий Владимирович
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Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology |
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The formation of hydrophilic pores in lipid bilayer during phase transition is described using Smolukhowski's equation with an additional term of the hydrophobic pore source. This term is added to account for defects in lipid packing during phase transition. We assume that the temporal sequence of the pores is a stochastic process, a non -stationary second- order Erlang flow. Flow characteristics depend on the equation solution and determine the formation times of the hydrophilic pore. The calculated distribution of the durations of intervals between hydrophilic pore formations is in a good agree ment with experimental data published before. In terms of this model we describe the influence of poly (ethylene glycol) on the pore formation frequency.
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PUBMED DOI |
Bilayer permeability during phase transition as an Erlang flow of hydrophilic pores resulting from diffusion in the radius space
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|
Аносов Андрей Анатольевич (Заведующий кафедрой)
Смирнова Елена Юрьевна (Доцент)
Несвижский Юрий Владимирович (Профессор)
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Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology |
|
|
The formation of hydrophilic pores in lipid bilayer during phase transition is described using Smolukhowski's equation with an additional term of the hydrophobic pore source. This term is added to account for defects in lipid packing during phase transition. We assume that the temporal sequence of the pores is a stochastic process, a non -stationary second- order Erlang flow. Flow characteristics depend on the equation solution and determine the formation times of the hydrophilic pore. The calculated distribution of the durations of intervals between hydrophilic pore formations is in a good agree ment with experimental data published before. In terms of this model we describe the influence of poly (ethylene glycol) on the pore formation frequency.
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тезис
PUBMED DOI |